TheGonyaulaxClock at 50: Translational Control of Circadian Expression
نویسندگان
چکیده
منابع مشابه
Translational control of gene expression and disease.
In the past decade, translational control has been shown to be crucial in the regulation of gene expression. Research in this field has progressed rapidly, revealing new control mechanisms and adding constantly to the list of translationally regulated genes. There is accumulating evidence that translational control plays a primary role in cell-cycle progression and cell differentiation, as well...
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In mammalian cells, the splicing machinery deposits the exon junction complex (EJC) on mRNA splice junctions. Two studies in this issue now link the EJC to different aspects of translational control. Ma et al. (2008) show that the EJC activates translation downstream of the mTOR signaling pathway, whereas Isken et al. (2008) establish that translation is repressed by partners of the EJC that ar...
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Much of our behavior and physiology exhibits daily oscillations driven by a circadian rhythm. While the phase of these oscillations is typically set by the daily light–dark cycle, the oscillations themselves are actually produced by an internal circadian clock. A summary of the Drosophila circadian clock mechanism, which exhibits evolutionary conservation with the human one, is outlined in Figu...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2007
ISSN: 0091-7451
DOI: 10.1101/sqb.2007.72.026